Evaluation Hepatitis C virus entry and neutralizing antibodies : lessons from viral variants
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HCV entry and neutralizing antibodies: lessons from viral variants.
Evaluation of: Grove J, Nielsen S, Zhong J et al.: Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies. J. Virol. 82 (24), 12020-12029 (2008). Recent data suggest that a strong, early, broad neutralizing antibody response may contribute to the control of HCV in the acute ph...
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End-stage liver disease caused by chronic hepatitis C virus (HCV) infection is a leading cause for liver transplantation (LT). Due to viral evasion from host immune responses and the absence of preventive antiviral strategies, reinfection of the graft is universal. The mechanisms by which the virus evades host immunity to reinfect the liver graft are unknown. In a longitudinal analysis of six H...
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Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing evidence that host neutralizing responses play a relevant role in the resulting pathogenesis. Furthermore, viral evasion from host neutralizing antibodies has been revealed to...
متن کاملHepatitis C virus plays hide and seek with neutralizing antibodies.
Hepatitis C virus (HCV) evades immune responses to establish a chronic infection. These viral evasion mechanisms pose a formidable challenge to vaccine development. In this issue of HEPATOLOGY Prentoe et al. report important observations that guide the development of vaccination strategies for induction of potent cross-neutralizing antibodies. While the importance of cellular immunity for contr...
متن کاملMutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.
BACKGROUND & AIMS The development of vaccines and other strategies to prevent hepatitis C virus (HCV) infection is limited by rapid viral evasion. HCV entry is the first step of infection; this process involves several viral and host factors and is targeted by host-neutralizing responses. Although the roles of host factors in HCV entry have been well characterized, their involvement in evasion ...
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تاریخ انتشار 2009